CPT Update 2025

The 2025 CPT Updated files below contain information on the CPT updates for FY 2025. These 2025 CPT codes are to be used for discharges occurring from January 1, 2025

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Surgery: Integumentary System

CPT® 2025 includes eight new codes for skin cell suspension autograft (SCSA). This technique includes the harvest and preparation of a liquid solution of skin cells that is applied to a wound site to promote healing. Included are codes for the skin harvesting determined by size (15011, 15012), preparation of the SCSA by size (15013, 15014), and application based on anatomic site and size (15015-15018).

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Surgery: Musculoskeletal System

Mediastinal lymphadenectomy code 21632 was deleted, and an editorial revision to excision code 21630 removed the semicolon, making it a standalone CPT® code.

Also in this subsection is new code 25448 for intercarpal or carpometacarpal joint arthroplasty with suspension, including transfer or transplant of tendon with interposition, when performed. Code 25447 was editorially revised and is now the parent code to 25448.

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Surgery: Cardiovascular System

Three codes were deleted in this subsection: pulmonary valve valvotomy code 33471; atrial septectomy or septostomy code 33737; and obliteration of aortopulmonary septal defect code 33813. With the deletion of code 33813, code 33814 was revised to no longer include a semicolon as the child code.

Surgery: Hemic and Lymphatic Systems

In this subsection, four new codes were added for chimeric antigen receptor T-cell (CAR-T) therapy. This is a type of immunotherapy that uses a patient’s own T cells to treat blood cancers.

• 38225 describes the harvesting of blood-derived T lymphocytes for development of genetically modified autologous CAR-T cells. This code is reported per day.

• 38226 is for preparation of blood-derived T lymphocytes for transportation.

• 38227 is for receipt and preparation of CAR-T cells for administration.

• 38228 is for CAR-T cell administration.

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Surgery: Digestive System

Five new codes, 49186-49190, were added to describe the excision or destruction of intra-abdominal tumors or cysts using an open surgical approach, including methods like cytoreduction or debulking.

These codes are based on the total length of the tumor(s) or cyst(s) removed or destroyed. Only the tumor or cyst is measured, not the surrounding tissue or margins. Measurement should be taken in situ and documented in the operative report.

If tumors arise directly from an organ or soft tissue, the appropriate organ or tissue resection code should be used; excision of separate tumor implants can be reported using the tumor excision codes. For example, if both a partial colectomy and a separate mesentery tumor excision are performed, you will report each procedure with the corresponding code.

With the creation of these new codes for excision or destruction of intra-abdominal tumors or cysts, codes 49203, 49204, and 49205 were deleted.

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Surgery: Urinary System

Bladder incision code 51030 for cystotomy or cystostomy; with cryosurgical destruction of intravesical lesion was deleted, and 51020 was revised to remove the semicolon since it is no longer a parent code for 51030.

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Also in this subsection, three new codes were added:

• 51721 describes the insertion of a transurethral ablation transducer used to deliver thermal ultrasound for the ablation of prostate tissue. It also includes the placement of a suprapubic tube during the same session, as well as the placement of an endorectal cooling device, if performed. This comprehensive procedure is used to treat prostate conditions using thermal ultrasound.

• 53865 describes the insertion of a temporary device for ischemic remodeling of bladder neck and prostate.

• 53866 describes catheterization with the removal of the temporal device for ischemic remodeling.

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Surgery: Male Genital System

Under Other procedures of the prostate, two new codes were added:

• 55881 describes the transurethral ablation of prostate tissue using thermal ultrasound, which includes the use of magnetic resonance imaging (MRI) guidance for precise targeting and monitoring of the ablation process. This approach ensures accurate tissue destruction for prostate treatment.

• 55882 involves the transurethral ablation of prostate tissue using thermal ultrasound with MRI guidance and monitoring but adds the insertion of a transurethral ultrasound transducer for delivering the thermal ultrasound. Additionally, it includes the placement of a suprapubic tube and an endorectal cooling device, when performed, during the same session to support the ablation procedure.

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Surgery: Female Genital System

Under Excision of the ovary, code 58957 was deleted. In its place, a parenthetical note refers you to see 49186, 49187, 49188, 49189, 49190 for resection [tumor debulking] of recurrent ovarian, endometrial, tubal, or primary peritoneal gynecological malignancies, with omentectomy, if performed, without lymphadenectomy.

Code 58958 was editorially revised to remove the semicolon, in indication of its new parent code status.

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Surgery: Endocrine System

In this subsection, two new codes describe the percutaneous ablation of thyroid nodules using radiofrequency, with imaging guidance:

• 60660 refers to the ablation of one or more thyroid nodules in one lobe or the isthmus.

• +60661 is an add-on code for the ablation of thyroid nodules in an additional lobe, performed in conjunction with the primary procedure (60660).

Both codes are specific to radiofrequency ablation techniques for thyroid nodules. The second code is reported only when additional lobes are treated.

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Surgery: Nervous System

A new family of codes describes thoracic and lower extremity fascial plane blocks, which are regional anesthesia techniques used to provide pain relief.

• 64466 refers to a unilateral thoracic fascial plane block administered via injection.

• 64467 describes a unilateral thoracic fascial plane block delivered through continuous infusion.

• 64468 involves a bilateral thoracic fascial plane block given by injection.

• 64469 represents a bilateral thoracic fascial plane block using continuous infusion.

• 64473 describes a unilateral lower extremity fascial plane block by injection.

• 64474 refers to a unilateral lower extremity fascial plane block through continuous infusion.

These codes specify whether the procedure is unilateral or bilateral and whether the block is administered by injection or continuous infusion, and include imaging guidance.

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Surgery: Eye and Ocular Adnexa

New code 66683 describes implantation of an iris prosthesis. The procedure includes suture fixation and repair or removal of the iris when performed concurrently.

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Radiology

Magnetic resonance (MR) procedures pose potential risks for patients with implanted medical devices or foreign bodies, as the magnetic field can cause injury or death. To ensure patient safety, these devices may need specific precautions, such as device reprogramming or positioning, depending on the implant’s MR labeling and FDA-approved instructions. Medical physics services may be provided during the MR exam, reported using the following new codes:

• 76014 describes MR safety assessment by trained clinical staff, including the identification and verification of implant or foreign body components from various sources (e.g., surgical reports, imaging, device databases). The assessment analyzes the MR conditional status of the components and consults professional guidance, with a written report. This is for the initial 15 minutes of service.

• +76015 is an additional service to 76014 for continued MR safety assessment, lasting each additional 30 minutes, with a written report.

• 76016 describes MR safety determination by a physician or qualified health professional, including the review of implant MR conditions, risk-benefit analysis of performing the MR exam, and determination of necessary equipment and expertise. A written report is included.

• 76017 describes custom MR safety planning and monitoring by a medical physicist or MR safety expert. It includes tailoring MR acquisition to restrictive requirements for MR conditional implants and risk mitigation for non-conditional implants or foreign bodies, with written report and physician review.

• 76018 describes MR safety preparation of implant electronics, including programming of pulse generators or transmitters to protect the device and the patient from risks during the MR procedure. This is supervised by a physician or qualified health professional, with a written report.

• 76019 describes MR safety implant positioning and/or immobilization under supervision of a physician or qualified health professional. This involves securing the implant from forces or changes caused by the MR environment, as well as preventing radiofrequency burns. A written report is included.

These codes are listed out of sequence and 76017-76019 are modifier 51 Multiple procedures exempt.

 

Pathology and Laboratory

In the Multianalyte Assays with Algorithmic Analyses (MAAA) subsection, two new CPT® codes were created: 81515 is for a real-time polymerase chain reaction (PCR) test for detecting bacterial vaginosis and vaginitis using vaginal-fluid specimens; and 81558 describes a test used in kidney transplantation medicine to monitor for allograft rejection.

In the Chemistry subsection, new codes 82233 and 82234 are tests for beta-amyloid; new code 83884 is a test for neurofilament light chain; and 84393 and 84395 are tests for tau, phosphorylated and tau, total, respectively.

There is a new immunology code, 86581, for Streptococcus pneumoniae antibody (IgG), serotypes.

There are three new microbiology codes for infectious agent detection by nucleic acid (DNA or RNA) for Helicobacter (87513), Mycobacterium tuberculosis (87564), and Pneumocystis jirovecii (87594).

There are also many new proprietary laboratory analyses (PLA) codes. These codes describe PLAs provided by either a single laboratory or licensed/marketed to multiple providing laboratories. This subsection includes MAAA and genomic sequencing procedures (GSP).

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Medicine

There are three new influenza virus vaccine product codes: 90637 is for quadrivalent (qIRV), mRNA; 30 mcg/0.5 mL dosage; 90638 is for quadrivalent (qIRV), mRNA; 60 mcg/0.5 mL dosage; and 90695 is for H5N8, derived from cell cultures.

Three new add-on codes were created for a vasoreactivity study (+93896), emboli detection without intravenous microbubble injection (+93897), and venous-arterial shunt detection with intravenous microbubble injection (+93898). All are performed with a complete transcranial Doppler (TCD) study of intracranial arteries (93886).

Code 96040 for medical genetics and genetic counseling services was deleted and a new code (96041) was created in its place.

Two new codes were created for administration of respiratory syncytial virus, monoclonal antibody: 96380 includes counseling and 96381 is for the administration without counseling.

Category III Codes

There are many new Category III codes created for new and emerging technology. Some examples include codes 0870T-0875T for subcutaneous peritoneal ascites pump procedures, 0877T-0881T for augmentative analysis of chest computed tomography imaging data, and 0913T-0914T for percutaneous transcatheter therapeutic drug delivery by intracoronary drug-delivery balloon.