2025 ICD-10-CM
These 2025 ICD-10-CM codes are to be used for discharges occurring from October 1, 2024 through September 30, 2025 and for patient encounters occurring from October 1, 2024 through September 30, 2025.
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The ICD-10-CM code set update for fiscal year (FY) 2025 was posted July 3 to the Centers for Medicare & Medicaid Services (CMS) website. The update, effective Oct. 1, includes 252 new codes, 36 code deletions, and 13 code revisions. In preparation for what’s to come, here’s a quick overview of those changes to the diagnosis code set.
Chapter 1 – There are no new codes in this chapter for certain infectious and parasitic diseases but A77.41 is revised to correct the spelling of “chaffeensis.”
Chapter 2 – Several codes are converted to parent codes and expanded with fifth character ‘A’ to indicate cancer “in remission.” For example, under C81 Hodgkin Lymphoma there are seven new codes that describe the various types of this disease while in remission (C81.0A-C81.9A).
Chapter 3 – Just one new code is added here: D61.03 Fanconi anemia.
Chapter 4 – Under E10 Type 1 diabetes mellitus, new codes are added for presymptomatic diagnoses (E10.A-). There are also new codes for hypoglycemia levels (E16.A-), carcinoid syndrome (E34.00-E34.09), Obesity class (E66.811-E66.813), disorders of citrate metabolism (E74.82-), and E88.82 Obesity due to disruption of MC4R pathway.
Chapter 5 – Under F50 Eating disorders there are several new codes for anorexia nervosa, restricting type (F50.010-F50.019), binge eating/purging type (F50.020-F50.029), bulimia nervosa (F50.20-F50.25), and binge eating disorder (F50.810-F50.819). Also new are F50.83 Pica in adults and F50.84 Rumination disorder in adults.
Chapter 6 – There are several changes under G40 Epilepsy and recurrent seizures including the addition of G40.84 KCNQ2-related epilepsy and four child codes (G40.841-G40.844) to specify whether or not the disease is intractable, with status epilepticus. There are also new codes for serotonin syndrome (G90.81), other disorders of the autonomic nervous system (G90.889), and developmental and epileptic encephalopathy (G93.45).
Chapter 7 – In this chapter, five fifth-character codes under H44.2 Degenerative myopia are revised to remove the reference to bilateral “eye.”
Chapter 8 – There are no changes for diseases of the ear and mastoid process (H60-H95).
Chapter 9 – Four new codes (I26.03-I26.04, I26.95-I26.96) expand the I26 Pulmonary embolism subcategory, and two existing codes (I26.93-I26.94) are revised to add the term “thrombotic.”
Chapter 10 – Under subcategory J21 Acute bronchiolitis there are several new codes for nasal valve collapse. The sixth-character codes specify the location of the collapse (internal/external) and the seventh character codes describe state of the condition (static/dynamic/unspecified).
Chapter 11 – In this chapter, there are several new fifth- and sixth-character codes under K60.3 Anal fistula, K60.4 Rectal fistula, and K60.5 Anorectal fistula to allow the practitioner to report whether the condition is simple or complex and initial, persistent, or recurrent.
Chapter 12 – Under L29 Pruritus, there are new codes for cholestatic pruritus (L29.81) and other pruritus (L29.89). And under L43 Lichen planus, six new fifth-character codes more fully describe lichen planopilaris (L66.10-L66.12, L66.19) and central centrifugal cicatricial alopecia (L66.81, L66.89).
Chapter 13 – There are several new codes for diseases of the musculoskeletal system and connective tissue. Under M51 Thoracic, thoracolumbar, and lumbosacral intervertebral disk disorders, there are new six-character codes that allow the practitioner to specify the location of pain more succinctly. And under subcategory M65 Synovitis and tenosynovitis, several fifth- and sixth-character codes are added to allow the practitioner to specify the location of the unspecified synovitis and tenosynovitis.
Chapter 14 – Other than the addition of an Excludes1 note under N39.0 Urinary tract infection, site not specified, there’s nothing exciting going on here.
Chapter 15 – This chapter has a few note changes to codes in subcategory O24 Diabetes mellitus in pregnancy, childbirth, and the puerperium.
Chapter 16 – There is the addition of one Excludes1 note under P72 Other transitory neonatal endocrine disorders.
Chapter 17 – In this chapter, there are three new codes for congenital malformations of aortic and mitral valves (Q23.81-Q23.82, Q23.88) and one new code for Kleefstra syndrome (Q87.86).
Chapter 18 – You’ll find one new code here for anosognosia (R41.85). Patients with this condition are unaware of their health conditions or problems, often due to dementia or Alzheimer’s.
Chapter 19 – Under subcategory T45 Poisoning by, adverse effect of an underdosing of primarily systemic and hematological agents, not elsewhere classified, there is new code T45.A Poisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs, followed by several new fifth- and sixth- character codes that specify the circumstances of the poisoning, adverse effect, or underdosing. And under T81.32 Disruption of internal operation (surgical) wound, not elsewhere classified, there are new sixth-character codes (T81.320-T81.329) to specify the wound location
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Chapter 20 – There are no changes in this chapter for external causes of morbidity.
Chapter 21 – In this final chapter of ICD-10-CM, there are new codes for reporting genetic susceptibility to various diseases such as epilepsy and neurodevelopmental disorders (Z15.1) and obesity (Z15.2). Additionally, the descriptor for subcategory Z17 is revised to expand the scope of hormones to include progesterone and human epidermal growth factor and to specify receptor status. Also new for FY 2025:
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Z51.A Encounter for sepsis aftercare;
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Two new social determinants of health codes for insufficient health insurance coverage (Z59.71) or welfare support (Z59.72);
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Several codes (Z67.A-) for identifying blood types using the Duffy blood group system;
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Two codes (Z68.55-Z68.56) for identifying pediatric body mass index percentiles;
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A code for reporting family history of familial adenomatous polyposis (Z83.72); and
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Four codes for reporting a personal history of specific types of colon polyps (Z86.0100-Z86.0102, Z86.0109).
Note: There are additional changes within the Alphabetic Index and Tabular list, such as revisions, inclusion terms, and parenthetical notes, which are not covered in this article.
External Cause of Injuries Index
In the ICD-10-CM External Cause of Injuries index, there are a few revisions, additions, and deletions to Sections A, E, P, and R. The affected entries are:
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Section A – Assault (homicidal) (by) (in) Y09
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Section E – Explosion (accidental) (of) (with secondary fire) W40.9; Exposure (to) X58
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Section P – Powder burn (by) (from)
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Rape (attempted) T74.2-; Recoil
Most of the changes are typographic corrections such as correcting the spelling of “hangun” to “handgun” and “firearn” to “firearm.”
Note: Typographic errors in code files released by CMS are typically corrected in code books published by AAPC, so you may not see these errors.
Table of Drugs
Added to the ICD-10-CM Table of Drugs and Chemicals, under Hydroxyzine, is the substance “antiallergic,” reported with T45.0X-. Also added, under Immune, is “checkpoint inhibitors,” reported with T45.AX- and “Immunostimulant drug,” reported with T45.AX-. A six character is needed to identify the circumstances of the poisoning.
Table of Neoplasms
There’s just one revision to the ICD-10-CM Table of Neoplasms for FY 2025. Flexing the power of the comma, under Neoplasm, neoplastic, the entry “odontogenic – see Neoplasm, jaw bone” is revised to “odontogenic – see Neoplasm, jaw, bone.”
Guidelines
There are minimal changes to the ICD-10-CM Official Guidelines for Coding and Reporting for FY 2025:
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Section I.C.1.d.5(b) adds T81.49 and O86.09 to the list of sepsis codes that should be sequenced first.
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Section I.C.2.e.(2) revises the first sentence to reiterate that “If a patient admission/encounter is chiefly for the administration of chemotherapy, immunotherapy or external beam radiation therapy, assign ….”
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Section I.C.2.s adds C84.7B to the list of codes to assign for breast implant-associated anaplastic large cell lymphoma; and Section I.C.2.t revises the guideline for secondary malignant neoplasm of lymphoid tissue.
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Section I.C.4.1(a) adds the guideline for E10.A- Type 1 diabetes mellitus, presymptomatic.
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Section I.21.C.3 includes a revision to account for the descriptor change to Z17.